Objective: Investigation of a colon specific multiparticulate system based on pH sensitive property and specific enzyme biodegradability was carried out. The basic design consists of pectin microspheres containing Tinidazole and coated with pH sensitive polymer Eudragit S100 so as to maintain the intactness of pectin microspheres till they reach colon. Materials and Methods: The Tinidazole microspheres were prepared in six batches by emulsion dehydration technique using different drug and polymer ratios and coated with Eudragit S100 by solvent evaporation method. Microspheres were evaluated for the particle size, encapsulation efficiency, in vitro release and organ distribution studies. Key findings: In vitro release studies revealed that the release of Tinidazole from the microspheres was mainly influenced by the polymer concentration and maximum release was found in colonic pH due to pH sensitive polymer, Eudragit S100. From the organ distribution studies it was found that the maximum concentration of drug was observed in colon after 6-8h. Conclusion: Eudragit coated pectin microspheres are promising controlled release carriers for colon targeted delivery of Tinidazole.
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